High-Purity Micheliolide CAS 68370-47-8 | Natural Sesquiterpene Lactone for Research

Micheliolide 98% (CAS: 68370-47-8) – Natural Sesquiterpene Lactone for Biomedical and Pharmaceutical Research

Product Name: Micheliolide
Synonyms: (−)-Micheliolide, Guaiacane sesquiterpene lactone, Natural lactone compound
CAS Number: 68370-47-8
Molecular Formula: C15H20O3
Molecular Weight: 248.32 g/mol
Appearance: White to off-white crystalline powder
Source: Extracted from Michelia compressa and Michelia champaca
Category: Natural sesquiterpene lactone / Bioactive phytochemical / Anti-inflammatory compound

🌿 What is Micheliolide?

Micheliolide (CAS: 68370-47-8) is a naturally occurring sesquiterpene lactone isolated from the Michelia genus (Magnoliaceae family). It is structurally related to parthenolide and guaianolide-type compounds, featuring an α-methylene-γ-lactone moiety known for strong biological reactivity and pharmacological potential.

As a bioactive plant-derived lactone, Micheliolide exhibits a variety of biological activities, including anti-inflammatory, anticancer, immunomodulatory, and neuroprotective effects. Recent studies highlight its promising role as a natural inhibitor of NF-κB and STAT3 pathways, making it a valuable small molecule in inflammation and cancer research.

Micheliolide also serves as a precursor for dimethylaminomicheliolide (DMAMCL) — a stable water-soluble derivative currently under investigation as a potential anticancer drug candidate. Its ability to modulate cellular signaling, induce apoptosis in tumor cells, and suppress inflammatory mediators such as IL-6, TNF-α, and COX-2 underscores its significance in modern biomedical studies.

We provide ≥98% high-purity Micheliolide, supported by complete analytical documentation (COA, HPLC, MS, NMR), ensuring consistency and reliability for scientific research and development.

🔬 Key Features & Benefits

💎 High Purity: ≥98% verified by HPLC – ideal for pharmaceutical and academic research applications
🌿 Natural Source: Extracted and refined from Michelia plant species
⚙️ Potent Bioactivity: Exhibits anti-inflammatory, anticancer, and immunoregulatory properties
📊 Research Grade: Suitable for use in molecular biology, pharmacology, and cell culture studies
📄 Full Analytical Support: COA, HPLC chromatograms, MS, and NMR spectra available upon request

📌 Applications

Pharmaceutical Research:
Explored for potential use in anticancer, anti-inflammatory, and immunomodulatory therapies.

Signal Pathway Studies:
Used to study NF-κB, STAT3, and ROS-related cellular signaling mechanisms.

Cancer Biology:
Evaluated for induction of apoptosis and suppression of tumor proliferation in various cancer models.

Inflammation & Immune Studies:
Applied in studies involving macrophage activation, cytokine regulation, and inflammatory mediator inhibition.

Drug Development Research:
Serves as a key intermediate in synthesizing dimethylaminomicheliolide (DMAMCL), a promising anticancer lead compound.

📊 Technical Specifications (≥98% Research Grade)

🧪 Analytical Testing & Quality Assurance

Each batch of Micheliolide undergoes rigorous analytical testing to ensure purity, consistency, and structural integrity.

• HPLC Purity: ≥98% verified by high-performance liquid chromatography

• Structural Confirmation: Validated by Mass Spectrometry (MS) and NMR (¹H & ¹³C)

• UV-Vis & IR Characterization: Confirms lactone and guaianolide structural features

• Residual Solvent Analysis: Conducted in accordance with ICH Q3C standards

• Moisture Content: ≤1.0%, measured by Karl Fischer titration

• Heavy Metals: ≤10 ppm (ICP-MS)

• Microbial Limits: Free from bacterial and fungal contamination

Each order is accompanied by a Certificate of Analysis (COA), HPLC chromatogram, and MS/NMR spectra for complete data traceability.

🌟 Why Choose Our Micheliolide (CAS: 68370-47-8)?

✅ Professional Manufacturer & Supplier – Specializing in natural sesquiterpene lactones and plant-derived bioactives
✅ High Analytical Purity – Verified by advanced HPLC, MS, and NMR instruments
✅ Flexible Supply Options – From small-scale research quantities to bulk manufacturing
✅ Trusted Worldwide – Supplied to pharmaceutical, nutraceutical, and academic research institutions
✅ Secure Global Shipping – Controlled packaging and temperature stability during delivery

📦 Packaging & Delivery

Standard Packaging: 20 mg, 100mg, 100mg, 1g,5g,10g,100g
Bulk Packaging: Available upon request
Custom Options: Tailored packing solutions for specific research or project needs

All shipments are handled under controlled, light-protected, and temperature-stable conditions to maintain product integrity during international transport.

📩 Order & Contact

Looking for high-purity Micheliolide (CAS: 68370-47-8) for anti-inflammatory, oxidative stress, or oncology research?
We supply ≥98% research-grade Micheliolide with complete analytical documentation and professional technical support.

🌐 Website: www.cqherb.com
📧 Contact us today for quotations, samples, or detailed technical data sheets.