Basic.info

Apigenin Trimethyl Ether (Methoxyflavone) 98%

CAS: 5631-70-9
Molecular Formula: C₁₈H₁₆O₅
Molecular Weight: 312.32 g/mol
Appearance: Yellow crystalline to off-white powder

Core Value Proposition

Multi-Pathway Anti-Inflammatory & Antioxidant Agent
≥98% Purity (HPLC-UV validated, λmax 332 nm)

• Anti-Inflammatory Modulator: Suppresses NF-κB signaling and downregulates COX-2 expression.

• Antioxidant Protector: Inhibits ROS generation and enhances cellular redox defense.

• Cytoprotective Role: Shields neurons and endothelial cells from oxidative stress-induced apoptosis.

Biologically Validated Functions

1. Anti-Inflammatory Benefits

• Cytokine Regulation: Reduces TNF-α (↓72%) and IL-1β (↓65%) in activated macrophages.

• Enzyme Inhibition: Inhibits COX-2 (IC₅₀: 18 μM) and iNOS expression (↓55%).

2. Antioxidant & Cellular Protection

• ROS Suppression: Decreases intracellular ROS by 68% at 20 μM.

• Enzyme Induction: Activates Nrf2/HO-1 pathway, enhancing antioxidant enzyme activity (2.6× vs. control).

3. Neurocognitive & Cardiovascular Support

• Neuroprotection: Prevents Aβ-induced neurotoxicity (cell viability ↑45%).

• Vascular Health: Improves endothelial nitric oxide production (↑38%) and reduces lipid peroxidation.

4. Anti-Cancer Potential*

• Apoptosis Induction: Upregulates Bax/Bcl-2 ratio in cancer cell lines.

• Cell Cycle Arrest: Inhibits proliferation via G2/M checkpoint modulation.
  *For research purposes only, not for therapeutic claims.

Technical Specifications

Research & Industrial Applications

Nutraceutical Formulations

• Anti-Inflammatory Complexes: 50–200 mg/day combined with quercetin or luteolin for synergistic effects.

• Cognitive Support Supplements: 10–30 mg/serving in nootropic blends.

Functional Foods

• Fortified Beverages: Nanoemulsion delivery improves solubility and bioavailability (↑2.7×).

• Healthy Oils: Stabilizes lipid systems with antioxidant properties.

Cosmeceutical Innovations

• Skin Anti-Aging Serums: 0.05–0.2% concentration reduces oxidative stress and glycation markers.

• UV Protection Formulas: Acts as a natural photo-protective agent in topical creams.

Competitive Advantages

• High Purity: ≥98% verified by HPLC, residual solvents <10 ppm.

• Stability: 24–36 months under recommended storage.

• Versatility: Applicable across nutraceuticals, functional foods, and cosmeceuticals.

Industrial Packaging

Stored at -20°C, O₂ <0.1%; stability verified under ICH Q1A guidelines.

Critical FAQs

Q: How to confirm anti-inflammatory activity?
A: Batch-specific COX-2 and NF-κB inhibition assay data available on request.

Q: Solubility solutions for formulation?
A: Phospholipid complexes and MCT oil carriers enhance bioavailability.

Q: Can it be used in skincare formulations?
A: Yes, validated stability in emulsions and serums at 0.05–0.2% concentration.