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Premium 6-Prenylnaringenin | CAS 68682-01-9 | 98% HPLC Certified for Export & Lab Use
6-Prenylnaringenin (6-PN, CAS 68682-01-9) is a potent and reversible inhibitor of Cav3.2 T-type calcium channels (IC₅₀ = 991 nM), widely used in neuroscience and pharmacological research. It demonstrates exceptional blood-brain barrier permeability, making it ideal for studying neuropathic and visceral pain mechanisms.
Produktname :
6-Prenylnaringenin (6-PN)CAS-Nr. :
68682-01-9Aussehen :
Off-white crystalline powderSpezifikation :
1%-98%🌿 6-Prenylnaringenin (6-PN)
CAS No.: 68682-01-9
Molecular Formula: C₂₀H₂₀O₅
Molecular Weight: 340.37
✅ Potent Phytoestrogen with Dual Activity
6-PN combines estrogenic and antioxidant properties, offering dual benefits:
Endocrine Modulation: Binds selectively to estrogen receptors (ERα/ERβ), alleviating menopausal symptoms (e.g., hot flashes, osteoporosis) without systemic risks of conventional hormone therapy.
Oxidative Defense: Scavenges free radicals via prenyl group, protecting against UV-induced skin damage and lipid peroxidation.
| Parameter | Detail |
|---|---|
| Purity Range | 1%, 5%, 10%, 20%, 50%, ≥98% (HPLC) |
| Identification | HPLC-UV, NMR, MS |
| Storage | ≤20°C (protected from light) |
| Shelf Life | 24 months |
| Appearance | Off-white crystalline powder (≥98%) Light yellow powder (5%-50% blends) |
Menopausal Symptom Relief
Efficacy: Mimics natural estrogen activity, significantly reducing Kupperman Menopause Index scores (e.g., improved hot flashes, mood swings).
Safety Profile: Non-carcinogenic alternative to synthetic estrogens (e.g., conjugated equine estrogens), minimizing breast/endometrial cancer risks.
Cardiometabolic Health
Lipid Regulation: Lowers total cholesterol (TC) by 10–15% and LDL-C/HDL-C ratio, supporting cardiovascular health in postmenopausal women.
Dermatological Applications
Collagen Synthesis: Enhances skin elasticity by stimulating collagen production.
UV Protection: Synergizes with sunscreens to reduce oxidative damage in cosmeceuticals.
| Sector | Use Cases |
|---|---|
| Pharmaceuticals | - Menopausal health capsules (e.g., 20–50 mg/day formulations) - Osteoporosis prevention adjuvants |
| Cosmeceuticals | - Anti-aging serums (0.5–2% concentration) - Antioxidant-boosted sunscreens |
| Functional Foods | - Hormone-balancing beverages (1–5% liquid suspensions) - Metabolic health bars |
🔬 Science-Backed Customization
Synergistic Blends: Pre-optimized with resveratrol for enhanced bioavailability or vitamin E for oxidative stability.
Solvent-Free Extraction: Patented supercritical CO₂ method ensures >99% purity and eco-friendly production.
🌐 Certified Quality & Safety
Compliance: ISO 9001, Non-GMO Project Verified.
Contaminant Control: Heavy metals <10 ppm (USP/EP), residual solvents undetectable.
| Weight | Packaging | Transport | Delivery Time |
|---|---|---|---|
| 10g–5kg | Vacuum foil bags + desiccant | DHL/FedEx | 3–7 days |
| 5kg–25kg | Gas-flushed food-grade buckets | Air freight | 5–10 days |
| >25kg | Fiber drums (ISO-certified) | Sea freight | 15–45 days |
Q: How is quality verified before ordering?
A: Free samples (1–20g) provided with batch-specific Certificate of Analysis (COA) detailing purity, heavy metals, and microbial limits.
Q: What is the minimum order quantity (MOQ)?
A: 10g for ≥98% purity, 1kg for blends (5–50%).
Q: Can you support custom formulations?
A: Yes! OEM services include pH-adjusted solutions (pH 3–7), solubility-enhanced emulsions, or blend optimization.
Q: Are regulatory documents available?
A: Full dossier (Specs, SDS, Non-GMO/Allergen Statements) compliant with FDA, EFSA, and COSMOS standards.
End-to-End Traceability: Sourced from EU-certified organic hops (Alpine regions), with blockchain-supported supply chain visibility.
R&D Collaboration: Co-develop application-specific formulations backed by clinical data on estrogenic activity and safety.
Aus Hopfen (Humulus lupulus) gewonnen, 8-Prenylnaringenin (8-PN) ist ein wirksames Phytoöstrogen mit selektiver Östrogenrezeptor-Modulator-Aktivität (SERM), das im Vergleich zu Soja-Isoflavone eine höhere Wirksamkeit bei der Linderung von Wechseljahrsbeschwerden wie Hitzewallungen und der Förderung der Knochengesundheit bietet und gleichzeitig durch die Regulierung des Akt-Signalwegs den Muskelerhalt ohne körperliche Betätigung unterstützt.
MEHR LESEN
Quelle: Humulus lupulus L. (Hopfen), unser Xanthohumol ist ein potentes prenyliertes Flavonoid, bekannt für seine hohe Bioaktivität und seine Rolle als primärer Wirkstoff in Hopfenextrakten. Erhältlich in verschiedenen Reinheitsgraden (1 %, 5 %, 10 % und 98 %) für unterschiedliche industrielle Anforderungen, wobei hochreine Varianten ein leuchtend gelbes, kristallines Aussehen aufweisen.
MEHR LESEN
Isoxanthohumol ist ein bioaktives Prenylflavonoid, das hauptsächlich aus Hopfen (Humulus lupulus) und Bier gewonnen wird. Diese wirksame Verbindung zeigt signifikante antiproliferative Effekte gegen mehrere menschliche Krebszelllinien und hemmt die metastatische Tumorentwicklung in vivo. Sie zeigt außerdem eine breite antivirale Wirkung gegen Herpesviren (HSV1/HSV2) und das Bovine Virusdiarrhoe-Virus (BVDV) und ist daher ein wertvoller Kandidat für die pharmazeutische und nutraceutische Forschung.
MEHR LESEN
6-Prenylnaringenin (6-PN, CAS 68682-01-9) is a potent and reversible inhibitor of Cav3.2 T-type calcium channels (IC₅₀ = 991 nM), widely used in neuroscience and pharmacological research. It demonstrates exceptional blood-brain barrier permeability, making it ideal for studying neuropathic and visceral pain mechanisms.
MEHR LESEN
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